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| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Borna Coric | Win | 6-1, 6-2 |
| Third Round | Denis Shapovalov | Loss | 6-3, 4-6, 6-7 (4-7) |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | John Millman | Win | 6-1, 6-3, 6-2 |
| Second Round | Donald Young | Win | 6-4, 6-2, 7-5 |
| Third Round | Karen Khachanov | Win | 6-1, 6-4, 7-6 (7-3) |
| Fourth Round | Gilles Muller | Loss | 3-6, 4-6, 6-3, 6-4, 13-15 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire | Win | 6-1, 6-4, 6-1 |
| Second Round | Robin Haase | Win | 6-1, 6-4, 6-3 |
| Third Round | Nikoloz Basilashvili | Win | 6-0, 6-1, 6-0 |
| Fourth Round | Roberto Bautista Agut | Win | 6-1, 6-2, 6-2 |
| Quarterfinals | Pablo Carreno Busta | Win | 6-2, 2-0 Retired |
| Semifinals | Dominic Thiem | Win | 6-3, 6-4, 6-0 |
| Final | Stan Wawrinka | Win | 6-2, 6-3, 6-1 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nicolas Almagro | Win | 3-0 Retired |
| Third Round | Jack Sock | Win | 6-3, 6-4 |
| Quarterfinals | Dominic Thiem | Loss | 4-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Fabio Fognini | Win | 7-6 (7-3), 3-6, 6-4 |
| Third Round | Nick Kyrgios | Win | 6-3, 6-1 |
| Quarterfinals | David Goffin | Win | 7-6 (7-3), 6-2 |
| Semifinals | Novak Djokovic | Win | 6-2, 6-4 |
| Final | Dominic Thiem | Win | 7-6 (10-8), 6-4 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Rogerio Dutra Silva | Win | 6-1, 6-2 |
| Third Round | Kevin Anderson | Win | 6-3, 6-4 |
| Quarterfinals | Hyeon Chung | Win | 7-6 (7-1), 6-2 |
| Semifinals | Horacio Zeballos | Win | 6-3, 6-4 |
| Final | Dominic Thiem | Win | 6-4, 6-1 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kyle Edmund | Win | 6-0, 5-7, 6-3 |
| Third Round | Alexander Zverev | Win | 6-1, 6-1 |
| Quarterfinals | Diego Schwartzman | Win | 6-4, 6-4 |
| Semifinals | David Goffin | Win | 6-3, 6-1 |
| Final | Albert Ramos-Vinolas | Win | 6-1, 6-3 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dudi Sela | Win | 6-3, 6-4 |
| Third Round | Philipp Kohlschreiber | Win | 0-6, 6-2, 6-3 |
| Fourth Round | Nicolas Mahut | Win | 6-4, 7-6 (7-4) |
| Quarterfinals | Jack Sock | Win | 6-2, 6-3 |
| Semifinals | Fabio Fognini | Win | 6-1, 7-5 |
| Final | Roger Federer | Loss | 3-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Guido Pella | Win | 6-3, 6-2 |
| Third Round | Fernando Verdasco | Win | 6-3, 7-5 |
| Fourth Round | Roger Federer | Loss | 2-6, 3-6 |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Mischa Zverev | Win | 6-4, 6-3 |
| Second Round | Paolo Lorenzi | Win | 6-1, 6-1 |
| Quarterfinals | Yoshihito Nishioka | Win | 7-6 (7-2), 6-3 |
| Semifinals | Marin Cilic | Win | 6-1, 6-2 |
| Final | Sam Querrey | Loss | 3-6, 6-7 (3-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Florian Mayer | Win | 6-3, 6-4, 6-4 |
| Second Round | Marcos Baghdatis | Win | 6-3, 6-1, 6-3 |
| Third Round | Alexander Zverev | Win | 4-6, 6-3, 6-7 (5-7), 6-3, 6-2 |
| Fourth Round | Gael Monfils | Win | 6-3, 6-3, 4-6, 6-4 |
| Quarterfinals | Milos Raonic | Win | 6-4, 7-6 (9-7), 6-4 |
| Semifinals | Grigor Dimitrov | Win | 6-3, 5-7, 7-6 (7-5), 6-7(4-7), 6-4 |
| Final | Roger Federer | Loss | 4-6, 6-3, 1-6, 6-3, 3-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Alexandr Dolgopolov | Win | 6-3, 6-3 |
| Second Round | Mischa Zverev | Win | 6-1, 6-1 |
| Quarterfinals | Milos Raonic | Loss | 6-4, 3-6, 4-6 |
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