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MLB Leaders |
| Rank | Name | Team | GP | GS | W | L | S | IP | H | R | ER | BB | K | Hld | BS | WHIP | ERA |
| 1 | Y. Darvish | Tex | 9 | 9 | 7 | 1 | 0 | 60.2 | 37 | 20 | 20 | 19 | 86 | 0 | 0 | 0.92 | 2.97 |
| 2 | C. Buchholz | Bos | 9 | 9 | 6 | 0 | 0 | 65.2 | 44 | 13 | 13 | 24 | 69 | 0 | 0 | 1.04 | 1.78 |
| 3 | M. Scherzer | Det | 8 | 8 | 5 | 0 | 0 | 54.1 | 42 | 25 | 24 | 12 | 68 | 0 | 0 | 0.99 | 3.98 |
| 4 | A. Sanchez | Det | 8 | 8 | 4 | 3 | 0 | 52.2 | 45 | 14 | 12 | 12 | 66 | 0 | 0 | 1.08 | 2.05 |
| 5 | F. Hernandez | Sea | 9 | 9 | 5 | 2 | 0 | 64.2 | 50 | 13 | 11 | 10 | 64 | 0 | 0 | 0.93 | 1.53 |
| 6 | J. Shields | KC | 9 | 9 | 2 | 4 | 0 | 66.0 | 48 | 19 | 18 | 15 | 62 | 0 | 0 | 0.95 | 2.45 |
| 7t | R. Dempster | Bos | 8 | 8 | 2 | 4 | 0 | 48.0 | 36 | 24 | 20 | 19 | 61 | 0 | 0 | 1.15 | 3.75 |
| 7t | C. Sale | CWS | 9 | 9 | 5 | 2 | 0 | 64.0 | 44 | 19 | 18 | 15 | 61 | 0 | 0 | 0.92 | 2.53 |
| 9t | J. Masterson | Cle | 9 | 9 | 6 | 2 | 0 | 63.0 | 50 | 22 | 22 | 24 | 60 | 0 | 0 | 1.17 | 3.14 |
| 9t | J. Verlander | Det | 9 | 9 | 4 | 4 | 0 | 54.0 | 50 | 21 | 19 | 20 | 60 | 0 | 0 | 1.30 | 3.17 |
| 11 | H. Iwakuma | Sea | 9 | 9 | 5 | 1 | 0 | 58.2 | 38 | 14 | 12 | 8 | 55 | 0 | 0 | 0.78 | 1.84 |
| 12 | C. Sabathia | NYY | 9 | 9 | 4 | 3 | 0 | 59.1 | 61 | 24 | 21 | 15 | 54 | 0 | 0 | 1.28 | 3.19 |
| 13 | A. Cobb | TB | 8 | 8 | 4 | 2 | 0 | 53.0 | 50 | 18 | 17 | 12 | 52 | 0 | 0 | 1.17 | 2.89 |
| 14t | M. Moore | TB | 8 | 8 | 7 | 0 | 0 | 48.0 | 29 | 13 | 13 | 25 | 51 | 0 | 0 | 1.13 | 2.44 |
| 14t | J. Peavy | CWS | 7 | 7 | 5 | 1 | 0 | 45.2 | 38 | 16 | 15 | 8 | 51 | 0 | 0 | 1.01 | 2.96 |
| 16t | J. Lester | Bos | 9 | 9 | 6 | 0 | 0 | 59.2 | 45 | 19 | 18 | 15 | 50 | 0 | 0 | 1.01 | 2.72 |
| 16t | C. Wilson | LAA | 9 | 9 | 3 | 3 | 0 | 55.2 | 53 | 29 | 23 | 30 | 50 | 0 | 0 | 1.49 | 3.72 |
| 18 | D. Price | TB | 9 | 9 | 1 | 4 | 0 | 55.0 | 65 | 39 | 32 | 14 | 49 | 0 | 0 | 1.44 | 5.24 |
| 19t | R. Dickey | Tor | 9 | 9 | 3 | 5 | 0 | 54.0 | 49 | 32 | 29 | 24 | 48 | 0 | 0 | 1.35 | 4.83 |
| 19t | D. Holland | Tex | 8 | 8 | 3 | 2 | 0 | 55.1 | 48 | 19 | 18 | 11 | 48 | 0 | 0 | 1.07 | 2.93 |